JWH-184 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the carbonyl-reduced derivative of related compound JWH-122. The binding affinity of JWH-184 for the CB1 receptor is reported as Ki= 23 ± 6 nM.
Little formal knowledge exists on 5-MAPB. It does not share the neurotoxicity of MDA caused by the alpha-methyldopamine metabolite.A study in rats indicated that the major metabolites of 5-MAPB are 5-APB and 3-carboxymethyl-4-hydroxymethamphetamine.
5-MAPB binds to the dopamine transporter in rat brain cells with a lower potency than cocaine. In silico data suggests that the primary action on dopamine is through reversal of the transporter to release dopamine. This is consistent with the effects and it is likely that it exerts a similar action on serotonin and norepinephrine transporters.
2-Fluoromethamphetamine (2-FMA) is a stimulant drug from the amphetamine family which has rarely been found possessed as a designer .Effects include euphoria, loss of appetite, increased energy,insomnia, and increased blood pressure.
25B-NBOMe (NBOMe-2C-B, Cimbi-36, Nova, BOM 2-CB) is a derivative of the phenethylamine psychedelic 2C-B, discovered in 2004 by Ralf Heim at the Free University of Berlin. It acts as a potent partial agonist for the 5HT2A receptor. Anecdotal reports from users suggest 25B-NBOMe to be an active hallucinogen at a dose of as little as 250–500 µg,making it a similar potency to other phenethylamine derived hallucinogens such as bromo-dragonfly. Duration of effects lasts about 12–16 hours.
The carbon-11 labeled version of this compound ([11C]Cimbi-36) was synthesized and validated as aradioactive tracer for positron emission tomography (PET) in Copenhagen. As a 5-HT2A receptor agonist PET radioligand, [11C]Cimbi-36 was hypothesized to provide a more functional marker of these receptors. Also, [11C]Cimbi-36 is investigated as a potential marker of serotonin release and thus could serve as an indicator of serotonin levels in vivo. [11C]Cimbi-36 is now undergoing clinical trials as a PET-ligand in humans.
FUB-AMB ADB-F 5F-MN24 MDP MAB-CHMINAC ADRAFINIL THJ2201 THJ018 2-A1MP IPO-33 U-47700
TH-PVP CIPVP 4-CPVP 4F-PHP(PV7) DIBUTYLONE(DIBU) THIRYLONE(ET) MMBC 2NMC(CMC)
CPRC(cmc,bmc) mphp pentylone cec mexedrone 5F-PVP MAPV 5F-PCN BK-EDBP(ET) CORORAN 4MPD
MED(ET,BK) BMK 5FADB 5FMADMB FUF and so on
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